HOXC12

Across TCGA cell cohorts, HOXC12 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,542 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOXC12-associated GO terms across cancer lineages are Nucleic acid catabolic process, U2-type prespliceosome assembly, and Protein-RNA complex assembly. Each is linked with HOXC12 in more than 6 cancer types. Because this analysis shows association rather than direction, both HOXC12-to-partner and partner-to-HOXC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid catabolic process grouped by HOXC12-low versus HOXC12-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC12→partner) and Y-score (partner→HOXC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nucleic acid catabolic process →	+0.056	+2.220	.002	.002	3	7
BONE	U2-type prespliceosome assembly →	+0.121	+2.630	.003	<.001	3	6
BONE	Protein-RNA complex assembly →	+0.103	+2.849	<.001	<.001	3	6
SKIN	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.062	+1.074	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic translation →	+0.076	+0.501	<.001	.006	3	6
LARGE_INTESTINE	Regulation of amine transport →	-0.071	-0.598	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,542 associations by consensus.

Nucleic acid catabolic process by HOXC12 expression — BONE

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