HOXC11

Across TCGA patient cohorts, HOXC11 protein abundance is significantly associated with the RNA expression of many other genes, with 1,574 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOXC11-associated genes across cancer lineages are WFDC2, HTATSF1, and TTC23. Each is linked with HOXC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC11-to-partner and partner-to-HOXC11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXC11 versus WFDC2 in BRCA, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC11→partner) and Y-score (partner→HOXC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WFDC2 →	-2.747	-1.135	.004	.002	3	1
BRCA	HTATSF1 →	-0.559	-1.242	<.001	<.001	3	1
BRCA	TTC23 →	+0.518	+0.876	.009	.006	3	1
BRCA	PODXL2 →	-1.287	-1.200	.001	.002	3	1
BRCA	ST6GALNAC5 →	-1.500	-1.125	.005	.007	3	1
BRCA	ATL2 →	-0.881	-1.344	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,574 associations by consensus.

HOXC11 vs WFDC2 — BRCA

Explore this scatter interactively →