HOXC11

Across TCGA patient cohorts, HOXC11 mutation is significantly associated with the RNA expression of many other genes, with 1,265 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC11-associated genes across cancer lineages are PHF5A, DOLPP1, and CHAF1A. Each is linked with HOXC11 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXC11-to-partner and partner-to-HOXC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by HOXC11-low versus HOXC11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC11→partner) and Y-score (partner→HOXC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.640	+3.000	<.001	.001	3	3
UCEC	DOLPP1 →	+0.682	+3.010	<.001	<.001	3	2
UCEC	CHAF1A →	+0.703	+3.021	<.001	<.001	3	2
UCEC	THOP1 →	+0.520	+3.502	.002	.002	3	2
UCEC	LMNB2 →	+0.708	+2.914	.001	.001	3	2
SKCM	OR5F2P →	+0.021	+4.039	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,265 associations by consensus.

PHF5A by HOXC11 expression — UCEC

Explore this box plot interactively →