HOXB9

Across TCGA pan-cancer cohorts, HOXB9 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HOXB9 data layer compared with 29 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher HOXB9 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HOXB9 expression acts as an unfavorable survival marker.

SCLC and PRAD are the cancer types where HOXB9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

HOXB9–SCLC (OS)

Open the SCLC breakdown →