HOXB9

Across TCGA patient cohorts, HOXB9 mutation is significantly associated with the RNA expression of many other genes, with 819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB9-associated genes across cancer lineages are MIR548AD, RNU6-497P, and TRIM77. Each is linked with HOXB9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB9-to-partner and partner-to-HOXB9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AD grouped by HOXB9-low versus HOXB9-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB9→partner) and Y-score (partner→HOXB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR548AD →	+0.338	+8.471	<.001	.005	3	2
LUAD	RNU6-497P →	+0.480	+4.481	<.001	.009	3	2
LUAD	TRIM77 →	+0.071	+4.888	<.001	.005	3	2
UCEC	RN7SL191P →	+0.260	+2.911	<.001	.003	3	2
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1
UCEC	LIN7C →	+0.741	+3.365	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 819 associations by consensus.

MIR548AD by HOXB9 expression — BRCA

Explore this box plot interactively →