HOXB9

Across TCGA patient cohorts, HOXB9 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB9-associated genes across cancer lineages are MEK1, Tuberin, and Caspase-8. Each is linked with HOXB9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB9-to-partner and partner-to-HOXB9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HOXB9-low versus HOXB9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB9→partner) and Y-score (partner→HOXB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.475	+3.459	.009	.005	3	1
UCEC	Tuberin →	+0.383	+3.459	.004	.005	3	1
UCEC	Caspase-8 →	-0.318	-2.321	.011	.035	3	1
UCEC	4E-BP1 →	+0.445	+3.351	.001	.005	3	1
UCEC	Chk1_pS345 →	-0.154	-3.000	.026	.036	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by HOXB9 expression — UCEC

Explore this box plot interactively →