HOXB8

Across TCGA pan-cancer cohorts, HOXB8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HOXB8 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher HOXB8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HOXB8 expression acts as an unfavorable survival marker.

LIHC, PRAD, and BLCA are the cancer types where HOXB8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →
PRAD	DFS	Median	All	0.111	0.886	<.001	8	view →
BLCA	DFS	Median	IV	0.090	0.480	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HOXB8–LIHC (OS)

Open the LIHC breakdown →