HOXB4

Across TCGA patient cohorts, HOXB4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,651 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HOXB4-associated proteins across cancer lineages are MTERF3, TLN2, and HOXB4_S116. Each is linked with HOXB4 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOXB4-to-partner and partner-to-HOXB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXB4 versus MTERF3 in BRCA, with a Pearson correlation of -0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB4→partner) and Y-score (partner→HOXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTERF3 →	-0.500	-1.313	<.001	<.001	3	5
LSCC	TLN2 →	+0.457	+0.756	<.001	<.001	3	4
UCEC	HOXB4_S116 →	+2.166	+2.914	<.001	.003	3	4
LUAD	HOXB6 →	+1.276	+1.560	.002	<.001	3	4
BRCA	HOXB6_S214 →	+1.703	+1.746	<.001	<.001	3	4
COAD	SFRP2 →	+1.180	+0.978	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,651 associations by consensus.

HOXB4 vs MTERF3 — BRCA

Explore this scatter interactively →