HOXB4

Across TCGA patient cohorts, HOXB4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,338 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOXB4-associated genes across cancer lineages are HOXB3, HOXB2, and HOXB5. Each is linked with HOXB4 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOXB4-to-partner and partner-to-HOXB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXB4 versus HOXB3 in HNSC, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB4→partner) and Y-score (partner→HOXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HOXB3 →	+2.331	+1.914	<.001	.006	3	5
UCEC	HOXB2 →	+2.140	+1.100	<.001	.001	3	5
UCEC	HOXB5 →	+2.474	+1.099	<.001	.002	3	4
UCEC	HOXB-AS3 →	+2.997	+1.324	<.001	<.001	3	4
UCEC	HOXB-AS1 →	+1.054	+1.267	<.001	<.001	3	3
UCEC	HOXB-AS2 →	+2.853	+1.320	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,338 associations by consensus.

HOXB4 vs HOXB3 — HNSC

Explore this scatter interactively →