HOXB4

Across TCGA patient cohorts, HOXB4 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible HOXB4-associated genes across cancer lineages are MIR4769, CTAG1B, and RNU6-1026P. Each is linked with HOXB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXB4-to-partner and partner-to-HOXB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4769 grouped by HOXB4-low versus HOXB4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB4→partner) and Y-score (partner→HOXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4769 →	+0.585	+4.614	<.001	.006	3	3
LUAD	CTAG1B →	+0.161	+4.984	<.001	.005	3	2
UCEC	RNU6-1026P →	+0.427	+4.352	.001	.008	3	2
UCEC	RNU6-693P →	+0.275	+5.137	<.001	.003	3	2
LUSC	RPL21P126 →	+0.129	+4.447	.001	.006	3	2
LUSC	MIR6809 →	+0.419	+4.261	.009	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

MIR4769 by HOXB4 expression — SKCM

Explore this box plot interactively →