HOXB4

Across TCGA cell cohorts, HOXB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,904 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOXB4-associated GO terms across cancer lineages are Anterior/posterior pattern specification, Regulation of telomere capping, and Protein transmembrane transport. Each is linked with HOXB4 in more than 7 cancer types. Because this analysis shows association rather than direction, both HOXB4-to-partner and partner-to-HOXB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Anterior/posterior pattern specification grouped by HOXB4-low versus HOXB4-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB4→partner) and Y-score (partner→HOXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Anterior/posterior pattern specification →	+0.054	+1.089	.001	.004	3	8
LARGE_INTESTINE	Regulation of telomere capping →	+0.070	+1.184	<.001	<.001	3	8
PANCREAS	Protein transmembrane transport →	+0.028	+1.013	.007	.006	3	8
BLOOD_Myeloma	Positive regulation of stem cell differentiation →	-0.196	-1.263	.002	.002	2	7
STOMACH	Microtubule polymerization or depolymerization →	+0.076	+1.075	.006	.002	3	6
UPPER_AERODIGESTIVE_TRACT	Negative regulation of heterochromatin organization →	+0.081	+0.782	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,904 associations by consensus.

Anterior/posterior pattern specification by HOXB4 expression — BLOOD_Myeloma

Explore this box plot interactively →