HOXB4

Across TCGA cell cohorts, HOXB4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HOXB4-associated genes across cancer lineages are IL9, OR13C4, and C1QC. Each is linked with HOXB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB4-to-partner and partner-to-HOXB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL9 grouped by HOXB4-low versus HOXB4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB4→partner) and Y-score (partner→HOXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IL9 →	+0.037	+5.228	.001	.005	3	1
LUNG_NSCLC_LUAD	OR13C4 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	C1QC →	+0.022	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IL9 by HOXB4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →