HOXB3

Across TCGA patient cohorts, HOXB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,010 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HOXB3-associated proteins across cancer lineages are HOXB6_S214, HOXB4, and VCAN. Each is linked with HOXB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOXB3-to-partner and partner-to-HOXB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXB3 versus HOXB6_S214 in BRCA, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB3→partner) and Y-score (partner→HOXB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HOXB6_S214 →	+1.280	+1.456	<.001	<.001	3	5
HNSC	HOXB4 →	+1.914	+2.331	.006	<.001	3	5
BRCA	VCAN →	+0.954	+1.483	<.001	<.001	3	4
OV	CRYL1 →	+0.423	+1.447	<.001	<.001	3	4
BRCA	SEPTIN8 →	+0.378	+1.356	<.001	<.001	3	4
LUAD	SFRP2 →	+0.871	+0.961	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,010 associations by consensus.

HOXB3 vs HOXB6_S214 — BRCA

Explore this scatter interactively →