HOXB3

Across TCGA patient cohorts, HOXB3 mutation is significantly associated with the RNA expression of many other genes, with 1,254 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB3-associated genes across cancer lineages are LINC01941, LINC02222, and MRPL58. Each is linked with HOXB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXB3-to-partner and partner-to-HOXB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01941 grouped by HOXB3-low versus HOXB3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB3→partner) and Y-score (partner→HOXB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	LINC01941 →	+0.178	+3.991	<.001	<.001	3	3
CESC	LINC02222 →	+0.031	+5.252	<.001	.002	3	2
UCEC	MRPL58 →	+0.466	+2.616	<.001	.005	3	2
LUAD	LINC01162 →	+0.337	+2.588	<.001	.004	3	2
LUAD	TRAPPC2P7 →	+0.062	+4.602	<.001	.003	3	2
UCEC	SKA2 →	+0.669	+2.609	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,254 associations by consensus.

LINC01941 by HOXB3 expression — STAD

Explore this box plot interactively →