HOXB3

Across TCGA cell cohorts, HOXB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,459 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOXB3-associated GO terms across cancer lineages are Cilium movement, Golgi to plasma membrane protein transport, and Anterior/posterior pattern specification. Each is linked with HOXB3 in more than 9 cancer types. Because this analysis shows association rather than direction, both HOXB3-to-partner and partner-to-HOXB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium movement grouped by HOXB3-low versus HOXB3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB3→partner) and Y-score (partner→HOXB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cilium movement →	-0.055	-1.384	.001	.001	3	10
SKIN	Golgi to plasma membrane protein transport →	+0.092	+1.236	<.001	<.001	3	9
LUNG_SCLC	Anterior/posterior pattern specification →	+0.056	+2.997	<.001	<.001	3	9
CNS	Glycerophospholipid metabolic process →	+0.032	+1.489	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.068	+1.587	<.001	.001	3	8
URINARY_TRACT	Regulation of telomere capping →	+0.088	+1.287	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,459 associations by consensus.

Cilium movement by HOXB3 expression — LARGE_INTESTINE

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