HOXB3

Across TCGA cell cohorts, HOXB3 mutation is significantly associated with the RNA expression of many other genes, with 337 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXB3-associated genes across cancer lineages are CUEDC2, GUCA2A, and SAMM50. Each is linked with HOXB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB3-to-partner and partner-to-HOXB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUEDC2 grouped by HOXB3-low versus HOXB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB3→partner) and Y-score (partner→HOXB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUEDC2 →	+0.611	+3.064	.002	.009	3	2
BLOOD_Leukemia	GUCA2A →	+0.027	+4.232	<.001	<.001	3	2
LARGE_INTESTINE	SAMM50 →	+0.662	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TXN2 →	+0.596	+3.451	<.001	.002	3	1
LARGE_INTESTINE	TNRC6B →	+0.730	+3.364	.002	.002	3	1
LARGE_INTESTINE	ZBED4 →	+0.614	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 337 associations by consensus.

CUEDC2 by HOXB3 expression — LARGE_INTESTINE

Explore this box plot interactively →