HOXB2

Across TCGA patient cohorts, HOXB2 mutation is significantly associated with the RNA expression of many other genes, with 116 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HOXB2-associated genes across cancer lineages are RNU6-781P, NMS, and FAM30C. Each is linked with HOXB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXB2-to-partner and partner-to-HOXB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-781P grouped by HOXB2-low versus HOXB2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB2→partner) and Y-score (partner→HOXB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-781P →	+0.897	+5.888	<.001	.002	3	3
CESC	NMS →	+0.148	+5.837	<.001	.001	3	2
CESC	FAM30C →	+0.066	+5.569	<.001	.002	3	2
UCEC	RN7SKP132 →	+0.239	+4.877	<.001	.003	3	2
SKCM	LSP1P1 →	+0.217	+2.369	<.001	.008	3	2
LUAD	MTCYBP29 →	+0.406	+5.279	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

RNU6-781P by HOXB2 expression — LUAD

Explore this box plot interactively →