HOXB2

Across TCGA cell cohorts, HOXB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,543 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOXB2-associated GO terms across cancer lineages are Cellular response to morphine, Cellular response to isoquinoline alkaloid, and Positive regulation of cell-substrate junction organization. Each is linked with HOXB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both HOXB2-to-partner and partner-to-HOXB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to morphine grouped by HOXB2-low versus HOXB2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB2→partner) and Y-score (partner→HOXB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Cellular response to morphine →	+0.119	+2.370	.007	.002	3	8
URINARY_TRACT	Cellular response to isoquinoline alkaloid →	+0.119	+2.370	.007	.002	3	8
STOMACH	Positive regulation of cell-substrate junction organization →	+0.130	+2.447	.003	.003	3	7
BLOOD_Leukemia	Regulation of focal adhesion assembly →	+0.060	+2.022	<.001	<.001	3	6
BLOOD_Leukemia	Regulation of cell-substrate junction assembly →	+0.060	+2.022	<.001	<.001	3	6
LUNG_SCLC	Anterior/posterior pattern specification →	+0.059	+3.705	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,543 associations by consensus.

Cellular response to morphine by HOXB2 expression — URINARY_TRACT

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