HOXB2

Across TCGA cell cohorts, HOXB2 mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXB2-associated genes across cancer lineages are 150412, Ispinesib Mesylate, and Alectinib. Each is linked with HOXB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB2-to-partner and partner-to-HOXB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 150412 grouped by HOXB2-low versus HOXB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB2→partner) and Y-score (partner→HOXB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	150412 →	+0.333	+2.777	.049	.038	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.742	+2.652	.022	.045	3	1
LARGE_INTESTINE	Alectinib →	+0.564	+2.786	<.001	.037	3	1
LARGE_INTESTINE	PHA-793887 →	+0.739	+2.652	.044	.045	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.535	+2.652	.023	.045	3	1
LARGE_INTESTINE	Vincristine →	+0.855	+2.649	.049	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

150412 by HOXB2 expression — LARGE_INTESTINE

Explore this box plot interactively →