HOXA7

Across TCGA pan-cancer cohorts, HOXA7 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HOXA7 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HOXA7 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOXA7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, BLCA, and STAD are the cancer types where HOXA7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.038	0.783	<.001	18	view →
BLCA	OS	Median	IV	0.063	0.576	<.001	18	view →
STAD	DFS	Median	All	0.210	0.709	.010	9	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
UCEC	DFS	Median	All	0.918	0.633	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HOXA7–KIRP (DFS)

Open the KIRP breakdown →