HOXA5

Across TCGA pan-cancer cohorts, HOXA5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HOXA5 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher HOXA5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOXA5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

GBM, LUAD, and PDAC are the cancer types where HOXA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.199	0.521	.021	12	view →
LUAD	DFS	Median	All	1.000	0.574	.012	7	view →
PDAC	OS	Median	III,IV	0.377	0.930	.020	5	view →
LSCC	OS	Median	All	0.961	0.820	.010	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HOXA5–GBM (DFS)

Open the GBM breakdown →