HOXA4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HOXA4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA4-associated genes across cancer lineages are Notch1, Shc_pY317, and STAT3_pY705. Each is linked with HOXA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA4-to-partner and partner-to-HOXA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA4→partner) and Y-score (partner→HOXA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECNotch1 →+0.231+2.700<.001.00632
UCECShc_pY317 →-0.179-2.000.008.03232
UCECSTAT3_pY705 →-0.425-1.990<.001.03032
UCECDi-Ras3 →-0.186-2.000.005.03232
UCECEGFR_pY1173 →+0.109+2.026.002.01831
UCECeIF4G →+0.399+2.000.004.03231
Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration