HOXA3

Across TCGA patient cohorts, HOXA3 mutation is significantly associated with the RNA expression of many other genes, with 3,203 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA3-associated genes across cancer lineages are TBKBP1, PKN3, and ZMYND19. Each is linked with HOXA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXA3-to-partner and partner-to-HOXA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBKBP1 grouped by HOXA3-low versus HOXA3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA3→partner) and Y-score (partner→HOXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TBKBP1 →	+0.575	+3.611	.001	.001	3	3
UCEC	PKN3 →	+0.775	+2.212	<.001	<.001	3	3
UCEC	ZMYND19 →	+0.444	+3.906	<.001	<.001	3	3
LUAD	TMUB1 →	+0.594	+2.807	.001	.003	3	3
UCEC	DPM2 →	+0.336	+3.850	.001	<.001	3	3
SKCM	CSNK1E →	+0.427	+2.031	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,203 associations by consensus.

TBKBP1 by HOXA3 expression — LUAD

Explore this box plot interactively →