HOXA3

Across TCGA patient cohorts, HOXA3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA3-associated genes across cancer lineages are INPP4B, JNK2, and PDCD4. Each is linked with HOXA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA3-to-partner and partner-to-HOXA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by HOXA3-low versus HOXA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA3→partner) and Y-score (partner→HOXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.291	-2.222	.014	.009	3	2
UCEC	JNK2 →	+0.216	+1.495	.003	.034	3	2
UCEC	PDCD4 →	-0.668	-1.847	<.001	.008	3	2
UCEC	Shc_pY317 →	-0.130	-1.502	.020	.030	3	2
UCEC	Src_pY527 →	-0.414	-2.584	.008	.010	3	2
UCEC	Stathmin →	+0.144	+1.847	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

INPP4B by HOXA3 expression — UCEC

Explore this box plot interactively →