HOXA3

Across TCGA cell cohorts, HOXA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,136 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HOXA3-associated GO terms across cancer lineages are Regulation of cell-substrate adhesion, Ameboidal-type cell migration, and Positive regulation of protein localization to nucleus. Each is linked with HOXA3 in more than 8 cancer types. Because this analysis shows association rather than direction, both HOXA3-to-partner and partner-to-HOXA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate adhesion grouped by HOXA3-low versus HOXA3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA3→partner) and Y-score (partner→HOXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate adhesion →	+0.136	+1.555	<.001	<.001	3	9
BREAST	Ameboidal-type cell migration →	+0.084	+1.528	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein localization to nucleus →	+0.117	+1.655	<.001	<.001	3	9
BONE	Positive regulation of cell-substrate adhesion →	+0.115	+1.103	.002	.006	3	8
BONE	Positive regulation of cell-substrate junction organization →	+0.162	+1.277	<.001	<.001	3	8
BONE	Regulation of cell-matrix adhesion →	+0.133	+1.212	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,136 associations by consensus.

Regulation of cell-substrate adhesion by HOXA3 expression — BONE

Explore this box plot interactively →