HOXA2

Across TCGA patient cohorts, HOXA2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA2-associated genes across cancer lineages are p90 RSK, ACC1, and Notch1. Each is linked with HOXA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXA2-to-partner and partner-to-HOXA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by HOXA2-low versus HOXA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA2→partner) and Y-score (partner→HOXA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.169	+3.331	.027	.005	3	3
SKCM	ACC1 →	+0.427	+2.820	.016	.035	3	2
UCEC	Notch1 →	+0.202	+1.887	<.001	.029	3	2
UCEC	Annexin-1 →	+0.739	+2.720	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.678	+3.604	.004	.001	3	2
UCEC	Cyclin-B1 →	+0.652	+1.906	.003	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

p90 RSK by HOXA2 expression — UCEC

Explore this box plot interactively →