HOXA2

Across TCGA cell cohorts, HOXA2 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOXA2-associated genes across cancer lineages are GRIN2B, SLC35G3, and KRTAP6-1. Each is linked with HOXA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA2-to-partner and partner-to-HOXA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIN2B grouped by HOXA2-low versus HOXA2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA2→partner) and Y-score (partner→HOXA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GRIN2B →	+0.186	+3.554	.005	.007	3	2
URINARY_TRACT	SLC35G3 →	+0.006	+5.087	<.001	.004	3	1
PANCREAS	KRTAP6-1 →	+0.045	+4.614	<.001	.004	3	1
PANCREAS	OR10G4 →	+0.005	+4.614	<.001	.004	3	1
OVARY	OR2M4 →	+0.055	+3.700	.001	.005	3	1
OVARY	OR4C6 →	+0.085	+3.791	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GRIN2B by HOXA2 expression — BLOOD_Lymphoma

Explore this box plot interactively →