HOXA13

Across TCGA patient cohorts, HOXA13 mutation is significantly associated with the RNA expression of many other genes, with 3,267 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA13-associated genes across cancer lineages are AP1B1, ASCC2, and FOXRED2. Each is linked with HOXA13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA13-to-partner and partner-to-HOXA13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1B1 grouped by HOXA13-low versus HOXA13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA13→partner) and Y-score (partner→HOXA13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP1B1 →	+0.499	+4.031	<.001	<.001	3	2
UCEC	ASCC2 →	+0.260	+3.893	.002	<.001	3	2
UCEC	FOXRED2 →	+0.600	+1.906	<.001	.001	3	2
UCEC	SCO1 →	+0.512	+2.595	<.001	<.001	3	2
UCEC	RMC1 →	+0.407	+2.233	<.001	<.001	3	2
UCEC	GMPPA →	+0.357	+4.052	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,267 associations by consensus.

AP1B1 by HOXA13 expression — UCEC

Explore this box plot interactively →