HOXA1

Across TCGA pan-cancer cohorts, HOXA1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HOXA1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher HOXA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HOXA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

STAD, UCEC, and SKCM are the cancer types where HOXA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.001	0.660	<.001	30	view →
UCEC	DFS	Median	All	0.819	0.628	.012	28	view →
SKCM	DFS	Median	II,III,IV	0.852	0.559	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HOXA1–STAD (OS)

Open the STAD breakdown →