HOXA1

Across TCGA patient cohorts, HOXA1 protein abundance is significantly associated with the protein abundance of many other proteins, with 600 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HOXA1-associated proteins across cancer lineages are SIPA1L1_S1603, SLK_S344, and SP3_T115. Each is linked with HOXA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA1-to-partner and partner-to-HOXA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXA1 versus SIPA1L1_S1603 in PDAC, with a Pearson correlation of -0.57.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA1→partner) and Y-score (partner→HOXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SIPA1L1_S1603 →	-0.765	-1.280	<.001	.001	3	1
PDAC	SLK_S344 →	-0.766	-1.803	.002	.001	3	1
PDAC	SP3_T115 →	-1.045	-1.738	<.001	<.001	3	1
PDAC	SPN_S351 →	+0.918	+1.629	.001	<.001	3	1
PDAC	SRP54_S451 →	+0.690	+1.634	.001	<.001	3	1
PDAC	SRRM1_S431 →	+0.880	+1.843	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 600 associations by consensus.

HOXA1 vs SIPA1L1_S1603 — PDAC

Explore this scatter interactively →