HOXA1

Across TCGA cell cohorts, HOXA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,884 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOXA1-associated GO terms across cancer lineages are Embryonic neurocranium morphogenesis, Outer ear morphogenesis, and Cell-substrate adhesion. Each is linked with HOXA1 in more than 16 cancer types. Because this analysis shows association rather than direction, both HOXA1-to-partner and partner-to-HOXA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Embryonic neurocranium morphogenesis grouped by HOXA1-low versus HOXA1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA1→partner) and Y-score (partner→HOXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Embryonic neurocranium morphogenesis →	-0.224	-1.726	<.001	<.001	3	17
LIVER	Outer ear morphogenesis →	+1.973	+2.940	<.001	<.001	3	14
BONE	Cell-substrate adhesion →	+0.137	+1.172	<.001	<.001	3	9
BREAST	Response to type I interferon →	+0.097	+1.055	<.001	<.001	3	9
BLOOD_Leukemia	Schwann cell differentiation →	+0.052	+0.559	<.001	.001	3	9
STOMACH	Negative regulation of protein catabolic process →	+0.077	+1.669	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,884 associations by consensus.

Embryonic neurocranium morphogenesis by HOXA1 expression — OESOPHAGUS

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