HOTAIRM1

Across TCGA pan-cancer cohorts, HOTAIRM1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HOTAIRM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HOTAIRM1 RNA is repressed in tumor relative to normal tissue. In most cancer types HOTAIRM1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, HNSC, and KIRC are the cancer types where HOTAIRM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOTAIRM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.397	<.001	11	view →
HNSC	All	III,IV	+1.245	<.001	11	view →
KIRC	Male	II,III,IV	−0.785	<.001	8	view →
BRCA	All	III,IV	−1.899	<.001	6	view →
COAD	Female	All	−0.835	<.001	5	view →
LUSC	All	All	+0.423	.024	3	view →
CHOL	All	All	+1.268	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HOTAIRM1–KICH

Open the KICH breakdown →