HORMAD2

Across TCGA patient cohorts, HORMAD2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HORMAD2-associated genes across cancer lineages are EGFR_pY1068, EGFR, and ERK2. Each is linked with HORMAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HORMAD2-to-partner and partner-to-HORMAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HORMAD2-low versus HORMAD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HORMAD2→partner) and Y-score (partner→HORMAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.371	-3.700	.001	.001	3	1
UCEC	EGFR →	-0.281	-3.169	<.001	.019	3	1
UCEC	ERK2 →	+0.291	+2.321	.001	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.238	-3.321	.002	.010	3	1
UCEC	JNK2 →	+0.330	+2.584	<.001	.011	3	1
UCEC	Ku80 →	+0.323	+3.713	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by HORMAD2 expression — UCEC

Explore this box plot interactively →