HORMAD2

Across TCGA cell cohorts, HORMAD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 180 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HORMAD2-associated GO terms across cancer lineages are Regulation of protein K63-linked ubiquitination, Positive regulation of cytoplasmic translational initiation, and Neuron-neuron synaptic transmission. Each is linked with HORMAD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HORMAD2-to-partner and partner-to-HORMAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K63-linked ubiquitination grouped by HORMAD2-low versus HORMAD2-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HORMAD2→partner) and Y-score (partner→HORMAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of protein K63-linked ubiquitination →	+0.058	+0.043	.001	.009	3	3
BLOOD_Leukemia	Positive regulation of cytoplasmic translational initiation →	+0.078	+0.063	<.001	.007	3	3
BLOOD_Leukemia	Neuron-neuron synaptic transmission →	+0.072	+0.049	.001	.003	3	3
LUNG_NSCLC_LUAD	Negative regulation of canonical NF-kappaB signal transduction →	+0.036	+0.177	.001	.003	3	3
CNS	Negative regulation of leukocyte tethering or rolling →	-0.899	-0.077	.003	.002	2	3
LARGE_INTESTINE	Early endosome to Golgi transport →	+0.082	+0.020	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

Regulation of protein K63-linked ubiquitination by HORMAD2 expression — BLOOD_Leukemia

Explore this box plot interactively →