HORMAD2

Across TCGA cell cohorts, HORMAD2 mutation is significantly associated with the mutation status of many other genes, with 1,362 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HORMAD2-associated genes across cancer lineages are PPIL2, GGT1, and GGA1. Each is linked with HORMAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HORMAD2-to-partner and partner-to-HORMAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIL2 grouped by HORMAD2-low versus HORMAD2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HORMAD2→partner) and Y-score (partner→HORMAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPIL2 →	+3.479	+4.932	.002	.002	1	1
BLOOD_Leukemia	GGT1 →	+4.309	+4.560	.007	.007	1	1
BLOOD_Leukemia	GGA1 →	+4.894	+5.870	<.001	<.001	1	1
BLOOD_Leukemia	MICALL1 →	+2.894	+4.432	.005	.005	1	1
BLOOD_Leukemia	DEPDC5 →	+3.309	+4.794	.002	.002	1	1
BLOOD_Leukemia	CENPM →	+5.894	+5.321	.002	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,362 associations by consensus.

PPIL2 by HORMAD2 expression — BLOOD_Leukemia

Explore this box plot interactively →