HOOK3

Across TCGA pan-cancer cohorts, HOOK3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HOOK3 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HOOK3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HOOK3 expression acts as an unfavorable survival marker.

LSCC, PDAC, and UCEC are the cancer types where HOOK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.618	0.983	.028	8	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	4	view →
UCEC	DFS	Tertile	III,IV	0.487	1.000	.049	4	view →
HNSC	DFS	Tertile	All	0.437	0.708	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HOOK3–LSCC (OS)

Open the LSCC breakdown →