HOOK3

Across TCGA patient cohorts, HOOK3 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,196 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HOOK3-associated proteins across cancer lineages are COL8A1, FNTA, and MAN2A1. Each is linked with HOOK3 in more than 5 cancer types. Because this analysis shows association rather than direction, both HOOK3-to-partner and partner-to-HOOK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOOK3 versus COL8A1 in OV, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK3→partner) and Y-score (partner→HOOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COL8A1 →	+1.057	+0.914	<.001	<.001	3	6
LSCC	FNTA →	+0.249	+0.649	<.001	<.001	3	6
GBM	MAN2A1 →	-0.422	-0.290	.001	<.001	3	5
COAD	FERMT2 →	+0.521	+0.470	.001	.001	3	5
OV	POSTN →	+1.152	+0.964	.003	<.001	3	5
GBM	PSMB10 →	-0.359	-0.210	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,196 associations by consensus.

HOOK3 vs COL8A1 — OV

Explore this scatter interactively →