HOOK3

Across TCGA patient cohorts, HOOK3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,654 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HOOK3-associated genes across cancer lineages are MYL9, DDR2, and GPR176. Each is linked with HOOK3 in more than 8 cancer types. Because this analysis shows association rather than direction, both HOOK3-to-partner and partner-to-HOOK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOOK3 versus MYL9 in UCEC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK3→partner) and Y-score (partner→HOOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYL9 →	+1.173	+0.250	<.001	<.001	3	9
COAD	DDR2 →	+1.252	+0.392	<.001	<.001	3	8
OV	GPR176 →	+0.915	+0.288	<.001	<.001	3	8
COAD	MSRB3 →	+1.026	+0.219	<.001	<.001	3	8
OV	COL15A1 →	+1.343	+0.355	<.001	<.001	3	8
UCEC	SRPX →	+1.146	+0.285	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,654 associations by consensus.

HOOK3 vs MYL9 — UCEC

Explore this scatter interactively →