HOOK3

Across TCGA cell cohorts, HOOK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,616 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOOK3-associated GO terms across cancer lineages are Interkinetic nuclear migration, Microtubule anchoring, and Peptidyl-serine phosphorylation. Each is linked with HOOK3 in more than 19 cancer types. Because this analysis shows association rather than direction, both HOOK3-to-partner and partner-to-HOOK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interkinetic nuclear migration grouped by HOOK3-low versus HOOK3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK3→partner) and Y-score (partner→HOOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Interkinetic nuclear migration →	+0.112	+1.034	<.001	.001	3	20
UPPER_AERODIGESTIVE_TRACT	Microtubule anchoring →	+0.083	+0.940	.004	<.001	3	15
KIDNEY	Peptidyl-serine phosphorylation →	+0.098	+1.073	<.001	<.001	2	16
STOMACH	Microtubule anchoring at centrosome →	+0.106	+1.221	<.001	<.001	3	13
LARGE_INTESTINE	Microtubule anchoring at microtubule organizing center →	+0.105	+1.153	<.001	<.001	3	13
KIDNEY	Peptidyl-serine modification →	+0.096	+1.073	<.001	<.001	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,616 associations by consensus.

Interkinetic nuclear migration by HOOK3 expression — LIVER

Explore this box plot interactively →