HOOK2

Across TCGA pan-cancer cohorts, HOOK2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HOOK2 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HOOK2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HOOK2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where HOOK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.932	0.633	.002	31	view →
UCEC	DFS	Quartile	All	1.000	0.692	<.001	28	view →
PDAC	OS	Quartile	All	0.720	0.309	.001	20	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
GBM	OS	Median	All	0.426	0.635	.010	5	view →
LUAD	DFS	Quartile	All	0.422	0.782	.016	4	view →
HNSC	DFS	Median	II,III,IV	0.754	0.577	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HOOK2–LSCC (DFS)

Open the LSCC breakdown →