HOOK2

Across TCGA patient cohorts, HOOK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,060 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOOK2-associated proteins across cancer lineages are WIPF1, CC2D1A, and CD38. Each is linked with HOOK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOOK2-to-partner and partner-to-HOOK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOOK2 versus WIPF1 in GBM, with a Pearson correlation of -0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK2→partner) and Y-score (partner→HOOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WIPF1 →	-0.339	-0.456	<.001	.001	3	5
LUAD	CC2D1A →	+0.199	+0.544	<.001	<.001	3	5
BRCA	CD38 →	-0.803	-0.459	.003	.005	3	5
GBM	FMNL1_S1031 →	-0.690	-0.417	<.001	<.001	3	5
GBM	ILF3 →	+0.210	+0.403	<.001	<.001	3	5
OV	RFX1 →	+0.323	+1.138	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,060 associations by consensus.

HOOK2 vs WIPF1 — GBM

Explore this scatter interactively →