HOOK2

Across TCGA patient cohorts, HOOK2 mutation is significantly associated with the RNA expression of many other genes, with 2,275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOOK2-associated genes across cancer lineages are TRAJ42, MIR6858, and IGHVII-44-2. Each is linked with HOOK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOOK2-to-partner and partner-to-HOOK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ42 grouped by HOOK2-low versus HOOK2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK2→partner) and Y-score (partner→HOOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRAJ42 →	+0.861	+4.243	<.001	.009	3	3
HNSC	MIR6858 →	+0.694	+5.124	<.001	.008	3	2
HNSC	IGHVII-44-2 →	+0.265	+5.822	<.001	.003	3	2
LUSC	NOLC1P1 →	+0.063	+4.277	<.001	.001	3	2
LUSC	EIF3JP1 →	+0.192	+3.651	<.001	.003	3	2
LUSC	CYCSP35 →	+0.183	+3.446	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,275 associations by consensus.

TRAJ42 by HOOK2 expression — BRCA

Explore this box plot interactively →