HOOK1

Across TCGA pan-cancer cohorts, HOOK1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated HOOK1 data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HOOK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HOOK1 expression acts as an unfavorable survival marker.

BLCA, BRCA, and DLBC are the cancer types where HOOK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.130	0.684	<.001	21	view →
BRCA	OS	Median	All	0.656	0.924	.007	16	view →
DLBC	OS	Median	III,IV	0.172	0.907	<.001	12	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	9	view →
LUAD	OS	Median	All	0.372	0.700	.024	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUSC	OS	Median	II,III,IV	0.176	0.677	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

HOOK1–BLCA (OS)

Open the BLCA breakdown →