HOOK1

Across TCGA pan-cancer cohorts, HOOK1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HOOK1 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HOOK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HOOK1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and HNSC are the cancer types where HOOK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	1.000	0.870	.017	96	view →
LSCC	DFS	Median	II,III,IV	1.000	0.834	.004	14	view →
HNSC	DFS	Median	All	0.868	0.685	.013	6	view →
GBM	DFS	Tertile	All	0.896	0.629	.013	5	view →
LUAD	OS	Tertile	III,IV	0.876	0.259	.011	4	view →
UCEC	DFS	Quartile	III,IV	1.000	0.417	.040	4	view →
CCRCC	DFS	Median	All	1.000	0.733	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HOOK1–COAD (DFS)

Open the COAD breakdown →