HOOK1

Across TCGA patient cohorts, HOOK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,379 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HOOK1-associated proteins across cancer lineages are ACTR2, MAP7, and PLEKHO2. Each is linked with HOOK1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HOOK1-to-partner and partner-to-HOOK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOOK1 versus ACTR2 in BRCA, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK1→partner) and Y-score (partner→HOOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACTR2 →	-0.257	-0.721	<.001	.001	3	7
LUAD	MAP7 →	+0.450	+0.631	<.001	<.001	3	7
CCRCC	PLEKHO2 →	-0.310	-0.721	<.001	.001	3	6
GBM	ACTR3 →	-0.233	-0.643	<.001	<.001	3	6
OV	DOCK11 →	-0.480	-0.784	.001	<.001	3	6
LSCC	SIPA1 →	-0.304	-0.984	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,379 associations by consensus.

HOOK1 vs ACTR2 — BRCA

Explore this scatter interactively →