HOOK1

Across TCGA patient cohorts, HOOK1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,726 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOOK1-associated genes across cancer lineages are CRISPLD2, PRRX1, and ZEB2. Each is linked with HOOK1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HOOK1-to-partner and partner-to-HOOK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOOK1 versus CRISPLD2 in OV, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK1→partner) and Y-score (partner→HOOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CRISPLD2 →	-1.893	-0.394	<.001	<.001	3	9
OV	PRRX1 →	-1.767	-0.344	<.001	<.001	3	9
BRCA	ZEB2 →	-0.995	-0.400	<.001	<.001	3	9
CCRCC	C1orf210 →	+1.419	+0.356	<.001	<.001	3	9
UCEC	HTR2A →	-0.414	-0.440	.004	<.001	3	8
OV	IFFO1 →	-0.913	-0.483	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,726 associations by consensus.

HOOK1 vs CRISPLD2 — OV

Explore this scatter interactively →