HOOK1

Across TCGA patient cohorts, HOOK1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOOK1-associated genes across cancer lineages are 4E-BP1, eEF2, and 14-3-3_beta. Each is linked with HOOK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOOK1-to-partner and partner-to-HOOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by HOOK1-low versus HOOK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK1→partner) and Y-score (partner→HOOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.231	+2.459	.012	.018	3	2
SKCM	eEF2 →	+0.560	+2.824	.005	.034	3	2
UCEC	14-3-3_beta →	-0.086	-1.501	.011	.015	3	1
UCEC	JNK2 →	+0.175	+2.009	.009	.017	3	1
UCEC	Notch1 →	+0.122	+1.807	.010	.004	3	1
UCEC	p62 Lck ligand →	+0.368	+2.137	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

4E-BP1 by HOOK1 expression — UCEC

Explore this box plot interactively →