HOOK1

Across TCGA cell cohorts, HOOK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,259 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOOK1-associated GO terms across cancer lineages are Keratinocyte development, Negative regulation of mRNA catabolic process, and Negative regulation of Arp2/3 complex-mediated actin nucleation. Each is linked with HOOK1 in more than 12 cancer types. Because this analysis shows association rather than direction, both HOOK1-to-partner and partner-to-HOOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Keratinocyte development grouped by HOOK1-low versus HOOK1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK1→partner) and Y-score (partner→HOOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Keratinocyte development →	-0.477	-2.393	.005	.009	2	13
LIVER	Negative regulation of mRNA catabolic process →	+0.076	+2.687	.006	<.001	3	11
LIVER	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.235	+1.684	<.001	.003	3	11
BONE	Collagen fibril organization →	-0.330	-4.112	<.001	<.001	3	11
LUNG_SCLC	Cardiac muscle cell-cardiac muscle cell adhesion →	+0.259	+1.786	.004	<.001	3	11
URINARY_TRACT	Negative regulation of inflammatory response to wounding →	+0.223	+2.015	.008	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,259 associations by consensus.

Keratinocyte development by HOOK1 expression — BONE

Explore this box plot interactively →