HOOK1

Across TCGA cell cohorts, HOOK1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOOK1-associated genes across cancer lineages are LGALS12, G6PC2, and ZNF454. Each is linked with HOOK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOOK1-to-partner and partner-to-HOOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGALS12 grouped by HOOK1-low versus HOOK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK1→partner) and Y-score (partner→HOOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LGALS12 →	+0.114	+3.220	<.001	.002	3	1
LARGE_INTESTINE	G6PC2 →	+0.023	+2.921	.007	.005	3	1
LARGE_INTESTINE	ZNF454 →	+0.195	+2.921	.002	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+3.029	<.001	.003	3	1
LARGE_INTESTINE	WNT8A →	+0.028	+3.632	<.001	<.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

LGALS12 by HOOK1 expression — LARGE_INTESTINE

Explore this box plot interactively →