HOOK1

Across TCGA cell cohorts, HOOK1 mutation is significantly associated with the mutation status of many other genes, with 4,042 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOOK1-associated genes across cancer lineages are TMEM132D, NKTR, and TRPM4. Each is linked with HOOK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HOOK1-to-partner and partner-to-HOOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM132D grouped by HOOK1-low versus HOOK1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK1→partner) and Y-score (partner→HOOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMEM132D →	+3.357	+4.285	.005	.005	1	4
LARGE_INTESTINE	NKTR →	+2.777	+3.767	<.001	<.001	1	4
LARGE_INTESTINE	TRPM4 →	+2.000	+2.662	.008	.008	1	4
STOMACH	SIK3 →	+2.942	+4.025	.009	.009	1	3
STOMACH	PIK3CD →	+3.942	+4.584	.002	.002	1	3
STOMACH	TDRD15 →	+3.942	+4.584	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,042 associations by consensus.

TMEM132D by HOOK1 expression — STOMACH

Explore this box plot interactively →